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Injections are the most powerful placebo available
The first oral GLP-1 agonist drug approved by the FDA for type 2 diabetes and weight loss is oral semaglutide
These data are in line with the expectations generated by previous trials with GLP-1 agonists, such as LEADER and REWIND, and suggest that tirzepatide may exert a cardioprotective effect independent of glycemic control, possibly through anti-inflammatory mechanisms, improved endothelial function and lipid control
In humans, this is similar, with peaks generally being around 150pg/L in the serum
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